Characterization of wooden breast myopathy: a focus on syndecans and ECM remodeling

Sammendrag

The skeletal muscle deformity of commercial chickens (Gallus gallus), known as the wooden breast (WB), is associated with fibrotic myopathy of unknown etiology. For future breeding strategies and genetic improvements, it is essential to identify the molecular mechanisms underlying the phenotype. The pathophysiological hallmarks of WB include severe skeletal muscle fibrosis, inflammation, myofiber necrosis, and multifocal degeneration of muscle tissue. The transmembrane proteoglycans syndecans have a wide spectrum of biological functions and are master regulators of tissue homeostasis. They are upregulated and shed (cleaved) as a regulatory mechanism during tissue repair and regeneration. During the last decades, it has become clear that the syndecan family also has critical functions in skeletal muscle growth, however, their potential involvement in WB pathogenesis is unknown.

Les publikasjonen her:

DOI : doi.org/10.3389/fphys.2023.130...
NVA : hdl.handle.net/11250/3109739
NVA : hdl.handle.net/10852/106736
NVA : hdl.handle.net/11250/3109986