Characterization of wooden breast myopathy: a focus on syndecans and ECM remodeling
Publikasjonsdetaljer
Tidsskrift : Frontiers in Physiology , vol. 14 , p. 1–17 , 2023
Internasjonale standardnummer
:
Elektronisk
:
1664-042X
Publikasjonstype : Vitenskapelig artikkel
Lenker
:
DOI
:
doi.org/10.3389/fphys.2023.130...
ARKIV
:
hdl.handle.net/11250/3109739
Forskningsområder
Kvalitet og målemetoder
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Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no
Sammendrag
The skeletal muscle deformity of commercial chickens (Gallus gallus), known as the wooden breast (WB), is associated with fibrotic myopathy of unknown etiology. For future breeding strategies and genetic improvements, it is essential to identify the molecular mechanisms underlying the phenotype. The pathophysiological hallmarks of WB include severe skeletal muscle fibrosis, inflammation, myofiber necrosis, and multifocal degeneration of muscle tissue. The transmembrane proteoglycans syndecans have a wide spectrum of biological functions and are master regulators of tissue homeostasis. They are upregulated and shed (cleaved) as a regulatory mechanism during tissue repair and regeneration. During the last decades, it has become clear that the syndecan family also has critical functions in skeletal muscle growth, however, their potential involvement in WB pathogenesis is unknown.
