Publisert 2021

Les på engelsk

Publikasjonsdetaljer

Tidsskrift : PLOS ONE , vol. 16 , p. 1–14 , 2021

Internasjonale standardnummer :
Elektronisk : 1932-6203

Publikasjonstype : Vitenskapelig artikkel

Bidragsytere :

Sak : 2

Forskningsområder

Kvalitet og målemetoder

Har du spørsmål om noe vedrørende publikasjonen, kan du kontakte Nofimas bibliotekleder.

Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no

Sammendrag

Article Authors Metrics Comments Media Coverage Abstract 1. Introduction 2. Materials and methods 3. Results and discussion 4. Conclusion Supporting information References Reader Comments (0) Figures Abstract In this work, a new magnetic ligand fishing probe for discovery of DPP-IV inhibitory ligands was developed and it was tested as a proof of concept on the fruit extract of Vaccinium vitis-idaea (lingonberry). The ligands were shown to have appreciable dipeptidyl peptidase IV (DPP-IV) inhibitory activity (IC50: 31.8 μg mL-1).) Inhibition of DPP-IV is a well-known therapeutic approach for management of type 2 diabetes (T2D). DPP-IV was successfully immobilized onto magnetic beads and was shown to retain its catalytic activity and selectivity over a model mixture. A total of four ligands were successfully fished out and identified as cyanidin-3-galactoside (2), cyanidin-3-arabinoside (3), proanthocynidin A (4), and 10-carboxyl-pyranopeonidin 3-O-(6″-O-p-coumaroyl)-glucoside (5) using HPLC/HRMS.

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