Cellular heterogeneity in red and melanized focal muscle changes in farmed Atlantic salmon (Salmo salar) visualized by spatial transcriptomics
Publikasjonsdetaljer
Tidsskrift : Cell and Tissue Research , vol. 394 , p. 1–12 , 2023
Internasjonale standardnummer
:
Trykt
:
0302-766X
Elektronisk
:
1432-0878
Publikasjonstype : Vitenskapelig artikkel
Sak : 3
Lenker
:
DOI
:
doi.org/10.1007/s00441-023-038...
ARKIV
:
hdl.handle.net/11250/3110068
Forskningsområder
Avl og genetikk
Fisk i oppdrett
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Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no
Sammendrag
Spatial transcriptomics is a technique that provides insight into gene expression profiles in tissue sections while retaining structural information. We have employed this method to study the pathological conditions related to red and melanized focal changes in farmed Atlantic salmon (Salmo salar). Our findings support a model where similar molecular mechanisms are involved in both red and melanized filet discolorations and genes associated with several relevant pathways show distinct expression patterns in both sample types. Interestingly, there appears to be significant cellular heterogeneity in the foci investigated when looking at gene expression patterns. Some of the genes that show differential spatial expression are involved in cellular processes such as hypoxia and immune responses, providing new insight into the nature of muscle melanization in Atlantic salmon.
