Intergenerational effects of early life-stage temperature modulation on gene expression and DNA methylation in Atlantic cod (Gadus morhua)
Publikasjonsdetaljer
Tidsskrift : Epigenetics , vol. 18 , p. 1–14 , 2023
Internasjonale standardnummer
:
Trykt
:
1559-2294
Elektronisk
:
1559-2308
Publikasjonstype : Vitenskapelig artikkel
Sak : 1
Lenker
:
DOI
:
doi.org/10.1080/15592294.2023....
ARKIV
:
hdl.handle.net/11250/3091685
Forskningsområder
Avl og genetikk
Fisk i oppdrett
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Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no
Sammendrag
After suffering several collapses, the cod farming industry is now in the process of trying to re-establish itself. We have used material from Norway’s National Cod Breeding Program to study how different early life-stage temperature regimes affect DNA methylation and gene expression. Long-term effects were detected by sampling fish several weeks after the end of differential treatments, and offspring from the different exposure groups was also sampled. Many overlapping genes were found between the different exposure groups and generations, coupled with genes associated with differential CpG methylation levels. Genes involved in muscle fibre development, general metabolic processes and formation of deformities were significantly affected, and genes relevant for intergenerational transfer of epigenetic marks were also detected. We believe the use of environmental cues can be a useful strategy for improving the production of Atlantic cod.
