Replacing saturated fatty acids with polyunsaturated fatty acids increases the abundance of Lachnospiraceae and is associated with reduced total cholesterol levels-a randomized controlled trial in healthy individuals
Publikasjonsdetaljer
Tidsskrift : Lipids in Health and Disease , vol. 21 , p. 1–13 , mandag 26. september 2022
Internasjonale standardnummer
:
Elektronisk
:
1476-511X
Publikasjonstype : Vitenskapelig artikkel
Lenker
:
DOI
:
doi.org/10.1186/s12944-022-017...
ARKIV
:
hdl.handle.net/11250/3049362
Forskningsområder
Kosthold og helse
Kvalitet og målemetoder
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Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no
Sammendrag
Improving dietary fat quality strongly affects serum cholesterol levels and hence the risk of cardiovascular diseases (CVDs). Recent studies have identified dietary fat as a potential modulator of the gut microbiota, a central regulator of host metabolism including lipid metabolism. We have previously shown a significant reduction in total cholesterol levels after replacing saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFAs). The aim of the present study was to investigate the effect of dietary fat quality on gut microbiota, short-chain fatty acids (SCFAs), and bile acids in healthy individuals. In addition, to investigate how changes in gut microbiota correlate with blood lipids, bile acids, and fatty acids.
