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Publisert 2009

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Publikasjonsdetaljer

Tidsskrift : Chemometrics and Intelligent Laboratory Systems , vol. 98 , p. 10–23–14 , 2009

Utgiver : Elsevier

Internasjonale standardnummer :
Trykt : 0169-7439
Elektronisk : 1873-3239

Publikasjonstype : Vitenskapelig artikkel

Bidragsytere : Gjerstad, Øystein; Aakra, Ågot; Indahl, Ulf

Sak : 1

Har du spørsmål om noe vedrørende publikasjonen, kan du kontakte Nofimas bibliotekleder.

Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no

Sammendrag

Based on a recently developed spot segmentation method, we here present a new approach to modelling of individual spots in digital images, e.g. images of DNA microarrays. From the model parameter estimates and residuals we have developed an expedient approach to automatic quality assessment and identification of corrupted spots. The suggested approach to quality control is shown to give a statistically significant decrease of the variance in gene expression log-ratio estimates for three different DNA microarray datasets. (C) 2009 Published by Elsevier B.V.