Publisert 2024

Les på engelsk

Publikasjonsdetaljer

Tidsskrift : Nature Microbiology , vol. 9 , p. 3059–3074 , 2024

Internasjonale standardnummer :
Elektronisk : 2058-5276

Publikasjonstype : Vitenskapelig artikkel

Bidragsytere : Vera_Ponce_De_Leon, Arturo; Thiele, Ines; Hötzinger, Matthias; Gupta, Shashank; Johnsen, Sander Johan Mangseth; Rudi, Knut; Snipen, Lars-Gustav; Karlsen, Christian Renè; Hvidsten, Torgeir Rhoden; Sandve, Simen Rød; Pope, Phillip; Rosa, Sabina Leanti La

Forskningsområder

Avl og genetikk

Fôrutvikling og ernæring

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Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no

Sammendrag

To ensure sustainable aquaculture, it is essential to understand the path ‘from feed to fish’, whereby the gut microbiome plays an important role in digestion and metabolism, ultimately influencing host health and growth. Previous work has reported the taxonomic composition of the Atlantic salmon (Salmo salar) gut microbiome; however, functional insights are lacking. Here we present the Salmon Microbial Genome Atlas consisting of 211 high-quality bacterial genomes, recovered by cultivation (n = 131) and gut metagenomics (n = 80) from wild and farmed fish both in freshwater and seawater. Bacterial genomes were taxonomically assigned to 14 different orders, including 35 distinctive genera and 29 previously undescribed species. Using metatranscriptomics, we functionally characterized key bacterial populations, across five phyla, in the salmon gut. This included the ability to degrade diet-derived fibres and release vitamins and other exometabolites with known beneficial effects, which was supported by genome-scale metabolic modelling and in vitro cultivation of selected bacterial species coupled with untargeted metabolomic studies. Together, the Salmon Microbial Genome Atlas provides a genomic and functional resource to enable future studies on salmon nutrition and health.

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