Cold-pressed minke whale oil reduces circulating LDL/VLDL-cholesterol, lipid oxidation and atherogenesis in apolipoprotein E-deficient mice fed a Western-type diet for 13 weeks
Publikasjonsdetaljer
Tidsskrift : Nutrition & Metabolism , vol. 15 , p. 1–11 , 2018
Utgiver : BioMed Central (BMC)
Internasjonale standardnummer
:
Trykt
:
1743-7075
Elektronisk
:
1743-7075
Publikasjonstype : Vitenskapelig artikkel
Sak : 35
Lenker
:
ARKIV
:
http://hdl.handle.net/11250/25...
DOI
:
doi.org/10.1186/s12986-018-026...
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Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no
Sammendrag
Long-chain n3-polyunsaturated fatty acids (LC n3-PUFA) are well known for their anti-inflammatory activity and their impact on cardiovascular disease. Cold-pressed whale oil (CWO) has half the amount of LC n3-PUFA compared to cod liver oil (CLO). Still, there has been observed more pronounced beneficial effects on cardiovascular disease markers from intake of CWO compared to intake of CLO in human intervention studies. Extracts from CWO deprived of fatty acids have also been shown to display antioxidative and anti-inflammatory effects in vitro. The aim of this study was to investigate whether intake of a high-fat Western-type diet (WD) supplemented with CWO would prevent the development of atherosclerotic lesions in apolipoprotein E-deficient (ApoE−/−) mice.
