Vitenskapelig artikkel

Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation

Almeida, A. Filipa; Borge, Grethe Iren Andersen; Piskula, Mariusz; Tudose, Adriana; Tudoreanu, Liliana; Valentova, Katerina; Williamson, Gary; Santos, Claudia N.


Tidsskrift: Comprehensive Reviews in Food Science and Food Safety, vol. 17, p. 714–731, 2018

Utgave: 3

Internasjonale standardnumre:
Trykt: 1541-4337
Elektronisk: 1541-4337

Open Access: green


After consumption of plant-derived foods or beverages, dietary polyphenols such as quercetin are absorbed
in the small intestine and metabolized by the body, or they are subject to catabolism by the gut microbiota followed
by absorption of the resulting products by the colon. The resulting compounds are bioavailable, circulate in the blood
as conjugates with glucuronide, methyl, or sulfate groups attached, and they are eventually excreted in the urine. In
this review, the various conjugates from different intervention studies are summarized and discussed. In addition, the
substantial variation between different individuals in the measured quercetin bioavailability parameters is assessed in detail
by examining published human intervention studies where sources of quercetin have been consumed in the form of
food, beverages, or supplements. It is apparent that most reported studies have examined quercetin and/or metabolites
in urine and plasma from a relatively small number of volunteers. Despite this limitation, it is evident that there is less
interindividual variation in metabolites which are derived from absorption in the small intestine compared to catabolites
derived from the action of microbiota in the colon. There is also some evidence that a high absorber of intact quercetin
conjugates could be a low absorber of microbiota-catalyzed phenolics, and vice versa. From the studies reported so far,
the reasons or causes of the interindividual differences are not clear, but, based on the known metabolic pathways, it is
predicted that dietary history, genetic polymorphisms, and variations in gut microbiota metabolism would play significant
roles. In conclusion, quercetin bioavailability is subject to substantial variation between individuals, and further work is
required to establish if this contributes to interindividual differences in biological responses.