Publisert 2009

Les på engelsk


Tidsskrift : Journal of Fish Diseases , vol. 32 , p. 953–961–9 , 2009

Utgiver : Blackwell Publishing

Internasjonale standardnummer :
Trykt : 0140-7775
Elektronisk : 1365-2761

Publikasjonstype : Vitenskapelig artikkel

Bidragsytere : Alne, Henriette; Takle, Harald Rune; Terjesen, Bendik Fyhn; Thomassen, Magny Skinlo; Grammes, Fabian; Oehme, Maike Marlene; Refstie, Ståle; Sigholt, Trygve; Berge, Rolf Kristian; Rørvik, Kjell-Arne

Sak : 11

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Kjetil Aune


We have previously documented increased survival by feeding tetradecylthioacetic acid (TTA) during a natural outbreak of infectious pancreatic necrosis in post-smolt S1 Atlantic salmon. The aim of the present study was to test the effects of dietary TTA in S0 smolt at a location where fish often experience natural outbreaks of heart and skeletal muscle inflammation (HSMI) during their first spring at sea. The experimental groups were fed a diet supplemented with 0.25% TTA for a 6-week period prior to a natural outbreak of HSMI in May 2007. Relative percent survival for the groups fed TTA was 45% compared with control diets, reducing mortality from 4.7% to 2.5%. Expression of genes related to lipid oxidation was higher in cardiac ventricles from salmon fed TTA compared with controls. In addition, salmon fed TTA had periodically reduced levels of plasma urea, and increased cardiosomatic index and growth. Reduced mortality and increased growth after administration of TTA may be related to a combination of anti-inflammatory effects, and an altered metabolic balance with better protein conservation because of increased lipid degradation.