Nonlinear regulation enhances the phenotypic expression of trans-acting genetic polymorphisms
Publikasjonsdetaljer
Tidsskrift : BMC Systems Biology , vol. 1 , p. 12–1 , 2007
Utgiver : BioMed Central (BMC)
Internasjonale standardnummer
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Trykt
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1752-0509
Elektronisk
:
1752-0509
Publikasjonstype : Vitenskapelig artikkel
Sak : art. 32
Lenker
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OMTALE
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http://www.biomedcentral.com/1...
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Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no
Sammendrag
Conclusion: Our findings indicate that genetic variation affecting the form of cis-regulatory input functions may reshape the genotype-phenotype map by changing the relative importance of cis and trans variation. Our approach combining nonlinear dynamic models with statistical genetics opens up for a systematic investigation of how functional genetic variation is translated into phenotypic variation under various systemic conditions.