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Publisert 2020

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Publikasjonsdetaljer

Tidsskrift : ACS Omega , vol. 5 , 2020

Utgiver : American Chemical Society (ACS)

Internasjonale standardnummer :
Trykt : 2470-1343
Elektronisk : 2470-1343

Publikasjonstype : Vitenskapelig artikkel

Bidragsytere : Xu, Chao; Song, Dan; Holck, Askild Lorentz; Youyou, Zhou; Liu, Rong

Sak : 20

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Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no

Sammendrag

leic acid (OA), one of the most important monounsaturated fatty acids, possesses protective properties against chronic liver disease (CLD) development, but the underlying metabolic metabolism remains unknown. HPLC–MS-based lipidomics was utilized to identify and quantify the endogenously altered lipid metabolites when hepatocytes were exposed to OA administration. The identified lipids could be grouped into 22 lipid classes; of which, 10 classes were significantly influenced by the OA treatment: lysophosphatidylcholine (LPC), phosphatidylglycerol (PG), ceramides (Cer), hexosylceramides (Hex1Cer), dihexosylceramides (Hex2Cer), cholesterol ester (ChE), and coenzyme (Co) were decreased, while diglyceride (DG), triglyceride (TG), and acyl carnitine (AcCa) were increased. In addition, as the variable importance in projection (VIP) list (VIP > 1.0 and P < 0.05) showed, 478 lipid species showed significant difference with OA administration, and these molecules could be potential biomarkers in conjunction with OA administration. In summary, our results provided a novel perspective to understand the influences of OA administration by investigating endogenous altered levels of lipid metabolites via lipidomics.

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