Publisert 2017

Les på engelsk


Tidsskrift : PLOS ONE , vol. 12 , 2017

Internasjonale standardnummer :
Trykt : 1932-6203
Elektronisk : 1932-6203

Publikasjonstype : Vitenskapelig artikkel

Bidragsytere : Steppeler, Christina; Sødring, Marianne Sundt; Egelandsdal, Bjørg Tordis; Kirkhus, Bente; Oostindjer, Marije; Alvseike, Ole; Gangsei, Lars Erik; Hovland, Ellen Margrethe; Pierre, Fabrice; Paulsen, Jan Erik

Sak : 4

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Kjetil Aune


The International Agency for Research on Cancer has classified red meat as “probably carcinogenic to humans” (Group 2A). In mechanistic studies exploring the link between intake of red meat and CRC, heme iron, the pigment of red meat, is proposed to play a central role as a catalyzer of luminal lipid peroxidation and cytotoxicity. In the present work, the novel A/J Min/+ mouse was used to investigate the effects of dietary beef, pork, chicken, or salmon (40% muscle food (dry weight) and 60% powder diet) on Apc-driven intestinal carcinogenesis, from week 3–13 of age. Muscle food diets did not differentially affect carcinogenesis in the colon (flat ACF and tumors). In the small intestine, salmon intake resulted in a lower tumor size and load than did meat from terrestrial animals (beef, pork or chicken), while no differences were observed between the effects of white meat (chicken) and red meat (pork and beef). Additional results indicated that intestinal carcinogenesis was not related to dietary n-6 polyunsaturated fatty acids, intestinal formation of lipid peroxidation products (thiobarbituric acid reactive substances, TBARS), or cytotoxic effects of fecal water on Apc-/+ cells. Notably, the amount of heme reaching the colon appeared to be relatively low in this study. The greatest tumor load was induced by the reference diet RM1, underlining the importance of the basic diets in experimental CRC. The present study in A/J Min/+ mice does not support the hypothesis of a role of red meat in intestinal carcinogenesis.