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SNP detection on bovine chromosome 6

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Kjetil Aune

Bibliotekleder
kjetil.aune@nofima.no

43. NBS kontaktmøte 2007; Lillehammer, 2007-02-01–2007-02-04

Nilsen, Heidi; Lien, Sigbjørn

Bovine chromosome 6 (BTA6) is an interesting chromosome when it comes to mastitis resistance and milk production traits in the Norwegian Cattle population. Several putative quantitative trait loci (QTL) have been localized on this chromosome. We have constructed a dense genetic marker map consisting of 403 single nucleotide polymorphisms (SNPs) generated from PCR resequencing and from the Bovine Genome Sequencing Project. Comparison of this map and a map constructed using linkage disequilibrium information indicated variability in recombination rate across the chromosome. Further, investigation of the frequency of polymorphism in the resequencing data revealed an uneven distribution of SNPs across BTA6. Generally, less SNPs were detected in regions known to harbor quantitative trait loci (QTL) affecting milk production traits. These regions are expected to be under strong artificial selection in the Norwegian Red cattle population.