Atypical furunculosis vaccines for Atlantic cod (Gadus morhua); vaccine efficacy and antibody responses
Publikasjonsdetaljer
Tidsskrift : Vaccine , vol. 26 , p. 6791–6799 , 2008
Utgiver : Elsevier
Internasjonale standardnummer
:
Trykt
:
0264-410X
Elektronisk
:
1873-2518
Publikasjonstype : Vitenskapelig artikkel
Sak : 52
Lenker
:
DOI
:
doi.org/10.1016/j.vaccine.2008...
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Kjetil Aune
Bibliotekleder
kjetil.aune@nofima.no
Sammendrag
Atypical furunculosis caused by atypical Aeromonas salmonicida, is an emerging problem in farming of Atlantic cod (Gadus morhua) in Norway, and vaccines are needed. Atypical A. salmonicida comprises a heterogeneous group of bacteria differing in surface antigens such as the A-layer protein and lipopolysaccharides (LPS). Except for one of the experimental oil-adjuvanted whole cell vaccines based on various isolates they all resulted in moderate protection. No clear correlation between vaccine efficacies and the A-protein group or LPS type of the vaccine isolates was revealed, while a correlation between efficacy and the presence of cross-reacting LPS-specific antibodies is indicated.
