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Atypical furunculosis vaccines for Atlantic cod (Gadus morhua); vaccine efficacy and antibody responses

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Kjetil Aune

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kjetil.aune@nofima.no

Vaccine ; Volume 26. p. 6791–6799. 2008

Lund, Vera; Lund, Vera; Arnesen, Jan-Arne; Mikkelsen, Helene; Mikkelsen, Helene; Gravningen, Kjersti; Brown, Laura; Schrøder, Merete Bjørgan

Atypical furunculosis caused by atypical Aeromonas salmonicida, is an emerging problem in farming of Atlantic cod (Gadus morhua) in Norway, and vaccines are needed. Atypical A. salmonicida comprises a heterogeneous group of bacteria differing in surface antigens such as the A-layer protein and lipopolysaccharides (LPS). Except for one of the experimental oil-adjuvanted whole cell vaccines based on various isolates they all resulted in moderate protection. No clear correlation between vaccine efficacies and the A-protein group or LPS type of the vaccine isolates was revealed, while a correlation between efficacy and the presence of cross-reacting LPS-specific antibodies is indicated.

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