Academic article

Atypical furunculosis vaccines for Atlantic cod (Gadus morhua); vaccine efficacy and antibody responses

Lund, Vera; Arnesen, Jan Arne; Mikkelsen, Helene; Gravningen, Kjersti; Brown, Laura; Schrøder, Merete Bjørgan

Publication details

Journal: Vaccine, vol. 26, p. 6791–6799, 2008

Publisher: Elsevier

Issue: 52

International Standard Numbers:
Printed: 0264-410X
Electronic: 1873-2518

Open Access: none


Atypical furunculosis caused by atypical Aeromonas salmonicida, is an emerging problem in farming of Atlantic cod (Gadus morhua) in Norway, and vaccines are needed. Atypical A. salmonicida comprises a heterogeneous group of bacteria differing in surface antigens such as the A-layer protein and lipopolysaccharides (LPS). Except for one of the experimental oil-adjuvanted whole cell vaccines based on various isolates they all resulted in moderate protection. No clear correlation between vaccine efficacies and the A-protein group or LPS type of the vaccine isolates was revealed, while a correlation between efficacy and the presence of cross-reacting LPS-specific antibodies is indicated.