Academic article

Trifluoroacetylation of electron-rich thiophenes

Kristoffersen, Kenneth Aase; Benneche, Tore

Publication details

Journal: Journal of fluorine chemistry, vol. 176, p. 31–34, 2015

International Standard Numbers:
Printed: 0022-1139
Electronic: 1873-3328

Open Access: green


Electron-rich thiophenes were trifluoroacetylated by trifluoroacetic anhydride with different nitrogen bases in dichloromethane at room temperature in good yields. Trifluoroacetylation without a base gave significantly lower yields.