Promising bioactive fatty acid in fish feed

The bioactive fatty acid TTA in fish feed can have an extremely positive effect on fish health. A fresh doctoral thesis points to the fact that it has a similar effect on the heart as exercise.

TTA (Tetradecylthioacetic acid)

  • is a bioactive fatty acid, which has an effect on several biological processes, including metabolism and inflammatory reactions
  • a lot of research is carried out on TTA in mammals and human beings
  • intake of high concentrations of TTA may be harmful
  • TTA is not currently approved as an ingredient in feeds for animals

Fabian Grammes at Nofima has studied the use of tetradecylthioacetic acid (TTA) in feed for Atlantic salmon smolt in sea cages. Trials during a natural outbreak of heart and skeletal muscle inflammation (HSMI) showed a significantly lower mortality rate of Atlantic salmon that were fed the TTA supplemented diet than salmon which were not.

Grammes also observed increased relative heart weight and increased cardiac gene expression six weeks after TTA feeding ended. In addition, the study indicates that TTA increases the expression of genes that regulate the immune system.

Good for stressed fish

Grammes studied genetic expression in heart samples of Atlantic salmon unaffected by viral diseases, and these results confirm the profound effects of TTA in the trials involving exposure to HSMI.

“The hearts had increased metabolism, increased growth and an increased ability to contract,” says Grammes. “The increased cardiac performance that we found for TTA-fed fish indicates significant benefits for farmed salmon in stressful situations.”

However, Grammes emphasises that in order to substantiate these positive results on natural disease outbreaks, a challenge trial will be necessary. Physiological data is required to substantiate these results at gene level.

Immune stimulation

Laboratory studies of macrophage cells (macrophages are cells which can both increase and reduce inflammation) from the kidneys support the fish trials that point to the fact that TTA has a positive effect on the immune system. These results can explain the reduced mortality in the trial involving the HSMI outbreak. The scientists also tested the immune cells with an artificial virus and found that TTA has a positive effect.

“TTA can help us to understand how functional feed can influence fish health,” says Grammes.

Fabian Grammes (31) is from Berlin. His earlier education is from Freie Universität Berlin and Max Planck Institute for Molecular Genetics. Dr. Harald Takle from Nofima is his academic supervisor for the PhD project, which is entitled “Cardiac and immune modulatory effects of tetradecylthioacetic acid (TTA) in Atlantic salmon (Salmo salar L.)”. Grammes will present his Doctoral thesis at the Norwegian University of Life Sciences (UMB) in Ås on May 27.

This research is financed by the Research Council of Norway.

Fish health  

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