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Biography Lars Axelsson

Research interests and competence I belong to the microbiology group where I am mainly working in research projects related to the studies and applications of lactic acid bacteria (LAB) in food. These studies have been focused on basic research on the molecular biology of antimicrobial activity of LAB, such as bacteriocins; development of genetic tools for lactobacilli; physiology and genetics of lactic acid production; development and application of starter cultures for meat fermentation; development and application of protective cultures for meat and fish products; probiotic activity of LAB and identification/classification of bacteria using DNA techniques. These studies involve the use of both advanced methods in genetics and molecular biology, classical microbiology and fermentation technology. Education BSc in microbiology/biochemistry, Umeå University, Sweden (1984). PhD in microbiology (studies on Lactobacillus reuteri) from the Swedish University of Agricultural Sciences, Uppsala, Sweden (1990).

Lars Axelsson has 80 publications at Nofima:

Inorganic Nanocarriers for Encapsulation of Natural Antimicrobial Compounds for Potential Food Packaging Application: A Comparative Study

Gulin-Sarfraz, Tina; Kalantzopoulos, Georgios N.; Pettersen, Marit Kvalvåg; Åsli, Anette Wold; Tho, Ingunn; Axelsson, Lars Torsten; Sarfraz, Jawad

2021

Academic article

Probiotic Carnobacterium divergens increase growth parameters and disease resistance in farmed Atlantic cod (Gadus morhua) larvae without influencing the microbiota

Puvanendran, Velmurugu; Rud, Ida; Breiland, Mette Serine Wesmajervi; Arnesen, Jan-Arne; Axelsson, Lars Torsten

2021

Academic article

Surøl med karakter av Telemarksfrukt.

Axelsson, Lars Torsten

2020

Popular scientific article

Analysis of Megavariate Data in Functional Omics

Mosleth, Ellen Færgestad; McLeod, Anette; Rud, Ida; Axelsson, Lars ; Solberg, Lars Erik; Moen, Birgitte; Gilman, Krista Marie Erickson; Færgestad, Eline Mosleth; Lysenko, Artem; Rawlings, Chris; Dankel, Simon N; Mellgren, Gunnar; Barajas-Olmos, Francisco Martin; Orozco, Lorena Sofia ; Sæbø, Solve; Gidskehaug, Lars ; Janbu, Astrid Oust; Kohler, Achim; Martens, Harald Aagaard; Liland, Kristian Hovde

2020

Academic chapter/article/Conference paper

The effects of a pilot-scale steam decontamination system on the hygiene and sensory quality of chicken carcasses

Kure, Cathrine F.; Axelsson, Lars Torsten; Carlehög, Mats; Måge, Ingrid; Jensen, Merete Rusås; Holck, Askild Lorentz

2020

Academic article

Growth Behavior of Listeria monocytogenes in a Traditional Norwegian Fermented Fish Product (Rakfisk), and Its Inhibition through Bacteriophage Addition

Axelsson, Lars Torsten; Bjerke, Guro Alette; McLeod, Anette; Berget, Ingunn; Holck, Askild Lorentz

2020

Academic article

Bacteria for better taste

Lindberg, Diana; Axelsson, Lars Torsten

2019

Popular scientific article

Large Plasmid Complement Resolved: Complete Genome Sequencing of Lactobacillus plantarum MF1298, a Candidate Probiotic Strain Associated with Unfavorable Effect

McLeod, Anette; Fagerlund, Annette; Rud, Ida; Axelsson, Lars

2019

Academic article

Lactic acid bacteria: an introduction

von Wright, Atte; Axelsson, Lars

2019

Academic chapter/article/Conference paper

Exploring the brine microbiota of a traditional Norwegian fermented fish product (Rakfisk) from six different producers during two consecutive seasonal productions

Bjerke, Guro Alette; Rudi, Knut; Avershina, Ekaterina; Moen, Birgitte; Blom, Hans; Axelsson, Lars

2019

Academic article

Pretreatment of different food rest materials for bioconversion into fungal lipid-rich biomass

Tzimorotas, Dimitrios; Afseth, Nils Kristian; Lindberg, Diana; Kjørlaug, Oda Marie; Axelsson, Lars; Shapaval, Volha

2018

Academic article

Survival of Five Strains of Shiga Toxigenic Escherichia coli in a Sausage Fermentation Model and Subsequent Sensitivity to Stress from Gastric Acid and Intestinal Fluid

Rode, Tone Mari; McLeod, Anette; Måge, Ingrid; Heir, Even; Axelsson, Lars; Holck, Askild Lorentz

2017

Academic article

Effects of glucose availability in Lactobacillus sakei; metabolic change and regulation of the proteome and transcriptome

McLeod, Anette; Mosleth, Ellen Færgestad; Rud, Ida; Branco dos Santos, Filipe; Snipen, Lars-Gustav; Liland, Kristian Hovde; Axelsson, Lars

2017

Academic article

Health and safety considerations of fermented sausages

Holck, Askild Lorentz; Axelsson, Lars; McLeod, Anette; Rode, Tone Mari; Heir, Even

2017

Academic literature review

Rakfisk – særnorsk delikatesse til jul

Axelsson, Lars

2016

Popular scientific article

Effect of relevant environmental stresses on survival of enterohemorrhagic Esherichia coli in dry-fermented sausage

McLeod, Anette; Måge, Ingrid; Heir, Even; Axelsson, Lars; Holck, Askild Lorentz

2016

Academic article

Antimicrobial resistance and residues in the EU – current situation and possible countermeasures, emphasis on Campylobacter and Salmonella

Alakomi, Hanna-Leena; Höhl, Andreas; Horvatek, Danijela Tomic; Thomas, Miles; Bruggeman, Geert; Tassis, Panagiotis; Prukner-Radovcic, Estella; Tzika, Eleni; Axelsson, Lars; Kneifel, Wolfgang; Saarela, Maria

2016

Academic literature review

Fermented and ripened fish products in the northern European countries

Skåra, Torstein; Axelsson, Lars; Stefansson, Gudmundur; Ekstrand, Bo; Hagen, Helge

2015

Academic article

Immunomodulation of monocytes by probiotic and selected lactic acid bacteria

Jensen, Hanne; Drømtorp, Signe; Axelsson, Lars; Grimmer, Stine

2015

Academic article

Heterologous protein secretion in lactobacilli with modified pSIP vectors

Karlskås, Ingrid Lea; Maudal, Kristina; Axelsson, Lars; Rud, Ida; Eijsink, Vincent; Mathiesen, Geir

2014

Academic article

North European products

Holck, Askild Lorentz; Heir, Even; Johannessen, T.C.; Axelsson, Lars

2014

Academic chapter/article/Conference paper

Microbes versus microbes: Control of pathogens in the food chain

Jordan, Kieran; Dalmasso, Marion; Zentec, Juergen; Mader, Anneluise; Bruggerman, Geert; Wallace, John; De Medici, Dario; Fiore, Alfonsina; Prukner-Radovcic, Estella; Lukac, Maja; Axelsson, Lars; Holck, Askild Lorentz; Ingmer, Hanne; Malakauskas, Mindaugas

2014

Academic literature review

Predicting the concentration of verotoxin-producing Escherichia coli bacteria during processing and storage of fermented raw-meat sausages

Quinto, E.J.; Arinder, P.; Axelsson, Lars; Heir, Even; Holck, Askild Lorentz; Lindqvist, R.; Lindblad, M.; Andreou, P.; Lauzon, H.L.; Marteinsson, V. P; Pin, C.

2014

Academic article

Heterologous protein secretion in lactobacilli with modified pSIP vectors

Lea, Ingrid; Maudal, Kristina; Axelsson, Lars; Rud, ida; Eijsink, Vincent; Mathiesen, Geir

2014

Academic article

Role of Lactobacillus reuteri cell and mucusbinding protein A (CmbA) in adhesion to intestinal epithelial cells and mucus in vitro

Jensen, Hanne; Roos, S.; Jonsson, H.; Rud, ida; Grimmer, Stine; van Pijkeren, J.P.; Britton, R.A.; Axelsson, Lars

2014

Academic article

Establishment of a Simple Lactobacillus plantarum Cell Consortium for Cellulase-Xylanase Synergistic Interactions

Moraïs, Sarah; Shterzer, Naama; Grinberg, Inna Rozman; Mathiesen, Geir; Eijsink, Vincent; Axelsson, Lars; Lamed, Raphael; Bayer, Edward A.; Itzhak, Mizrahi

2013

Academic article

Genome sequence of Lactobacillus sakei subsp. sakei LS 25, a commercial starter culture strain for fermented sausage

McLeod, Anette; Brede, Dag Anders; Rud, Ida; Axelsson, Lars

2013

Academic article

Stronger T cell immunogenicity of ovalbumin expressed intracellularly in Gram-negative than in Gram-positive bacteria

Martner, Anna; Östman, Sofia; Lundin, Samuel; Rask, Carola; Björnsson, Viktor; Telemo, Esbjörn; Collins, L. Vincent; Axelsson, Lars; Wold, Agnes E.

2013

Academic article

Cleaning of conveyor belt materials using ultrasound in a thin layer of water

Axelsson, Lars; Holck, Askild lorentz; Rud, Ida; Samah, D; Tierce, P; Favre, M; Kure, Cathrine F.

2013

Academic article

Effects of post-processing treatments on sensory quality and Shiga toxigenic Escherichia coli reductions in dry-fermented sausages

Heir, Even; Holck, Askild Lorentz; Omer, Mohammed K.; Alvseike, Ole; Måge, Ingrid; Høy, Martin; Rode, Tone Mari; Sidhu, Maan Singh; Axelsson, Lars

2013

Academic article

Heterogeneity in resistance to food-related stresses and biofilm formation ability among verocytotoxigenic Escherichia coli strains

Alvarez-Ordonez, A.; Alvseike, Ole; Omer, M.K.; Heir, Even; Axelsson, Lars; Holck, Askild lorentz; Prieto, M.

2013

Academic article

Shiga toxigenic Escherichia coli show strain dependent reductions under dry-fermented sausage production and post-processing conditions

Rode, Tone Mari; Holck, Askild lorentz; Axelsson, Lars; Høy, Martin; Heir, Even

2012

Academic article

Genome Sequence of the Naturally Plasmid-Free Lactobacillus plantarum Strain NC8 (CCUG 61730)

Axelsson, Lars; Rud, Ida; Naterstad, Kristine; Blom, Hans; Renckens, Bernadet; Boekhorst, Jos; Kleerebezem, Michiel; van Hijum, Sacha; Siezen, Roland J.

2012

Academic article

Microarray-based transcriptome of Listeria monocytogenes adapted to sublethal concentrations of acetic acid, lactic acid, and hydrochloric acid

Tessema, Girum Tadesse; Møretrø, Trond; Snipen, Lars; Heir, Even; Holck, Askild lorentz; Naterstad, Kristine; Axelsson, Lars

2012

Academic article

In vitro testing of commercial and potential probiotic lactic acid bacteria

Jensen, Hanne; Grimmer, Stine J Staavi; Naterstad, Kristine; Axelsson, Lars

2012

Academic article

Global transcriptome response in Lactobacillus sakei during growth on ribose

McLeod, Anette; Snipen, Lars-Gustav; Naterstad, Kristine; Axelsson, Lars

2011

Academic article

Functional analysis of the role of CggR (central glycolytic gene regulator) in Lactobacillus plantarum by transcriptome analysis

Rud, Ida; Naterstad, Kristine; Bongers, Roger S.; Molenaar, Douwe; Kleerebezem, Michiel; Axelsson, Lars

2011

Academic article

High Stability of Stx2 Phage in Food and under Food-Processing Conditions

Rode, Tone Mari; Axelsson, Lars; Granum, Per Einar; Heir, Even; Holck, Askild lorentz; L'Abée-Lund, Trine

2011

Academic article

Reduction of verotoxigenic Escherichia coli in production of fermented sausages

Holck, Askild lorentz; Axelsson, Lars; Rode, Tone Mari; Høy, Martin; Måge, Ingrid; Alvseike, Ole; L'Abée-Lund, Trine; Omer, MK; Granum, Per Einar; Heir, Even

2011

Academic article

Global Transcriptional Analysis of Spontaneous Sakacin P-Resistant Mutant Strains of Listeria monocytogenes during Growth on Different Sugars

Tessema, Girum Tadesse; Møretrø, Trond; Snipen, Lars-Gustav; Axelsson, Lars; Naterstad, Kristine

2011

Academic article

Intra- and Interlaboratory Performances of Two Commercial Antimicrobial Susceptibility Testing Methods for Bifidobacteria and Nonenterococcal Lactic Acid Bacteria

Huys, Geert; D'Haene, Klaas; Cnockaert, Margo; Tosi, Lorenzo; Danielsen, Morten; Florez, A.B.; Matto, Jaano; Axelsson, Lars; Korhonen, Jenni; Mayrhofer, Sigrid; Egervarn, Maria; Giacomini, Mauro; Vandamme, Peter

2010

Academic article

Reduction of verotoxigenic Escherichia coli by process and recipe optimisation in dry-fermented sausages

Heir, Even; Holck, Askild lorentz; Omer, Mohammed K.; Alvseike, Ole; Høy, Martin; Måge, Ingrid; Axelsson, Lars

2010

Academic article

Application of high pressure processing to reduce verotoxigenic E-coli in two types of dry-fermented sausage

Omer, Mohamed; Alvseike, Ole; Holck, Askild lorentz; Axelsson, Lars; Prieto, M.; Skjerve, Eystein; Heir, Even

2010

Academic article

Primary metabolism in Lactobacillus sakei food isolates by proteomic analysis

McLeod, Anette; Zagorec, Monique; Champomier-Verges, Marie-Christine; Naterstad, Kristine; Axelsson, Lars

2010

Academic article

A candidate probiotic with unfavourable effects in subjects with irritable bowel syndrome: a randomised controlled trial

Ligaarden, Solveig Catharina; Axelsson, Lars; Naterstad, Kristine; Lydersen, Stian; Farup, Per Grønaas

2010

Academic article

Complex Phenotypic and Genotypic Responses of Listeria monocytogenes Strains Exposed to the Class IIa Bacteriocin Sakacin

Tessema, Girum Tadesse; Møretrø, Trond; Kohler, Achim; Axelsson, Lars; Naterstad, Kristine

2009

Academic article

Genome-wide analysis of signal peptide functionality in Lactobacillus plantarum WCFS1

Mathiesen, Geir; Sveen, Anita; Brurberg, May Bente; Fredriksen, Lasse; Axelsson, Lars; Eijsink, Vincent

2009

Academic article

The ace-art database – antibiotic susceptibility of lactic acid bacteria and bifidobacteria in relation to their biological, geographical and chronological origin

Domig, Konrad J.; Mayrhofer, Sigrid; Huys, Geert; Tosi, Lorenzo; Danielsen, Morten; Mayo, B.; Axelsson, Lars; Korhonen, Jenni; Egervarn, Maria; Bardowski, Jacek K.; Saarela, Maria; Morelli, Lorenzo; Kneifel, Wolfgang

2008

Academic article

Antimicrobial susceptibility and proposed microbiological cut-off Values of lactobacilli by phenotypic determination

Korhonen, J.M.; Danielsen, M.; Mayo, B.; Egervarn, Maria; Axelsson, Lars; Huys, Geert; Wright, A

2008

Academic article

Co-factor engineering in lactobacilli: Effects of uncoupled ATPase activity on metabolic fluxes in Lactobacillus (L.) plantarum and L. sakei

Rud, Ida; Solem, Christian; Jensen, Petter Ruhdal; Axelsson, Lars; Naterstad, Kristine

2008

Academic article

Diversity of Lactobacillus sakei strains investigated by phenotypic and genotypic methods

McLeod, Anette; Nyquist, Otto Ludvig; Snipen, Lars; Naterstad, Kristine; Axelsson, Lars

2008

Academic article

Heterologous protein secretion by Lactobacillus plantarum using homologous signal peptides

Mathiesen, Geir; Sveen, Anita; Piard, JC; Axelsson, Lars; Eijsink, Vincent

2008

Academic article

Characterisation of the gap Operon from Lactobacillus plantarum and Lactobacillus sakei

Naterstad, Kristine; Rud, Ida; Kvam, Ingebjørg; Axelsson, Lars

2007

Academic article

Isolation of constitutive variants of a subfamily 10 histidine protein kinase (SppK) from Lactobacillus using random mutagenesis

Mathiesen, Geir; Axelsen, Gunnhild W.; Eijsink, Vincent; Axelsson, Lars

2006

Academic article

A synthetic promoter library for constitutive gene expression in Lactobacillus plantarum

Rud, Ida; Jensen, Petter Ruhdal; Naterstad, Kristine; Axelsson, Lars

2006

Academic article

Isolation of constitutive variants of a subfamily 10 histidine protein kinase (SppK) from Lactobacillus using random mutagenesis

Mathiesen, Geir; Axelsen, Gunnhild W.; Axelsson, Lars; Eijsink, Vincent

2006

Academic article

Improved expression and purification of the correctly folded response regulator PlnC from lactobacilli

Straume, Daniel; Axelsson, Lars; Nes, Ingolf F.; Diep, Dzung Bao

2006

Academic article

Characterization of a new bacteriocin operon in sakacin P-producing Lactobacillus sakei, showing strong translational coupling between the bacteriocin and immunity genes

Mathiesen, Geir; Huehne, Kathrin; Kroeckel, Lothar; Axelsson, Lars; Eijsink, Vincent

2005

Academic article

Sakacin P non-producing Lactobacillus sakei strains contain homologues of the sakacin P gene cluster

Møretrø, Trond; Naterstad, Kristine; Wang, Ellen; Aasen, Inga Marie; Chaillou, Stephane; Zagorec, Monique; Axelsson, Lars

2005

Academic article

Identification of potential probiotic starter cultures for Scandinavian-type fermented sausages

Klingberg, Trine Danø; Axelsson, Lars; Naterstad, Kristine; Elsser, Dieter; Budde, Birgitte Bjørn

2005

Academic article

Plasmid p256 from Lactobacillus plantarum represents a new type of replicon in lactic acid bacteria and contains a toxin-antitoxin plasmid maintenance system

Sørvig, Elisabeth; Skaugen, Morten; Naterstad, Kristine; Eijsink, Vincent; Axelsson, Lars

2005

Academic article

Characterization of a new bacteriocin operon in sakacin P-producing lactobacillus sakei showing strong translational coupling between the bacteriocicn and immunity genes

Mathiesen, Geir; hühne, k; Naterstad, Kristine; kröckel, lothar; Axelsson, Lars; Eijsink, Vincent

2005

Academic article

Bacterial lessons in sausage making

Eijsink, Vincent; Axelsson, Lars

2005

Academic article

High-level, inducible gene expression in Lactobacillus sakei and Lactobacillus planatarum using versatile expression vectors

Sørvig, Elisabeth; Mathiesen, Geir; Naterstad, Kristine; Eijsink, Vincent; Axelsson, Lars

2005

Academic article

The lactic acid bacteria, the food chain, and their regulation

Wessels, Stephen; Axelsson, Lars; Hansen, Egon; de Vuyst, Luc; Laulund, Svend; Lahteenmaki, Liisa; Lindgren, Sven; Mollet, Beat; vin Wrigth, Atte

2004

Academic article

Use of bacteriocin promoters for gene expression in Lactobacillus plantarum C11

Mathiesen, Geir; Namløs, Heidi Marie; Risøen, Per Arne; Axelsson, Lars; Eijsink, Vincent

2004

Academic article

High-level gene expression in Lactobacillus plantarum using a pheromone-regulated bacteriocin promoter

Mathiesen, Geir; Sørvig, Elisabeth; Blatny, Janet; Naterstad, Kristine; Axelsson, Lars; Eijsink, Vincent

2004

Academic article

Interactions of the bacteriocins sakacin P and nisin with food constituents

Aasen, Inga Marie; Markussen, Sidsel; Møretrø, Trond; Katla, Tone; Axelsson, Lars; Naterstad, Kristine

2003

Academic article

Differences in susceptibility of Listeria monocytogenes strains to sakacin P, sakacin A, pediocin PA-1 and nisin

Katla, T; Naterstad, Kristine; Vancanneyt, M.; Swings, J.; Axelsson, Lars

2003

Academic article

Development of an inducible gene expression system for Lactobacillus sakei

Axelsson, Lars; Lindstad, G.; Naterstad, Kristine

2003

Academic article

Construction of vectors for inducible gene expression in Lactobacillus sakei and L. plantarum

Sørvig, Elisabeth; Grönqvist, Sonja; Naterstad, Kristine; Mathiesen, Geir; Eijsink, Vincent; Axelsson, Lars

2003

Academic article

Inhibition of Listeria monocytogenes in chicken cold cuts by addition of sakacin P and sakacin P-producing Lactobacillus sakei

Katla, Tone; Møretrø, Trond; Sveen, I; Aasen, Inga Marie; Axelsson, Lars; Rørvik, Liv Marit; Naterstad, Kristine

2002

Academic article

Production of class II bacteriocins by lactic acid bacteria; an example of biological warfare and communication

Eijsink, Vincent; Axelsson, Lars; Diep, Dzung Bao; Håvarstein, Leiv Sigve; Holo, Helge; Nes, Ingolf F.

2002

Academic article

Inhibition of Listeria monocytogenes in cold smoked salmon by addition of sakacin P and/or live Lactobacillus sakei cultures

Katla, Tone; Møretrø, Trond; Aasen, Inga Marie; Holck, Askild Lorentz; Axelsson, Lars; Naterstad, Kristine

2001

Academic article

Characterization and growth of Bacillus spp. in heat-treated cream with and without nisin

Nissen, Hilde; Holo, Helge; Axelsson, Lars; Blom, Hans

2001

Academic article

The synthesis of the bacteriocin sakacin A is a temperature-sensitive process regulated by a pheromone peptide through a three-component regulatory system

Diep, Dzung Bao; Axelsson, Lars; Grefsli, Camilla; Nes, Ingolf F.

2000

Academic article

A C-terminal disulfide bridge in pediocin-like bacteriocins renders bacteriocin activity less temperature dependent and is a major determinant of the antimicrobial spectrum

Fimland, Gunnar; Johnsen, Line; Axelsson, Lars; Brurberg, May Bente; Nes, Ingolf F.; Eijsink, Vincent G. H.; Nissen-Meyer, Jon

2000

Academic article

Characterization, production, and purification of leucocin H, a two-peptide bacteriocin from Leuconostoc MF215B

Blom, Hans; Katla, Tone; Holck, Askild Lorentz; Sletten, Knut; Axelsson, Lars; Holo, Helge

1999

Academic article

Characterization, Production, and Purification of Leucocin H, a Two-Peptide Bacteriocin from Leuconostoc MF215B

Blom, Hans; Katla, Tone; Holck, Askild; Sletten, Knut; Axelsson, Lars; Holo, Helge

1999

Academic article

A new, completely defined medium for meat lactobacilli

Møretrø, Trond; Hagen, Beate Furuto; Axelsson, Lars

1998

Academic article

FoodMicro-Pack

1. January 2017 – 31. December 2020

The main goal of the strategic research program FoodMicro-Pack is to contribute to production and offering of safe and durable food, optimal packaging concepts and reduced food waste in the Norwegian food sector.